The Atherosclerosis is just known to be a very systematic disease related to artery. It is a disease which is known to be affecting to the almost the entire artery tree of the body of the person suffering from it. At the same time the pathophysiology of atherosclerosis usually related to changes in the major functions of the artery. The very simple change in the functions is to preventing the proper and required amount of oxygenated blood to the parts of the body. The doctors detect the Atherosclerosis by the lesions in the lower extremity circulations, extracranial cerebral and the coronary.
Mostly the medium sized and large sized arteries are known to be affected from it. The fatty plaque is mostly responsible for the pathophysiology of Atherosclerosis. The cerebral and the coronary artery system are also most commonly impacted from it. Strokes and heart attack are the result of which. Some less common effect of the pathophysiology are the peripheral vascular diseases. Smoking, hypertension, racial and familial factors, genetic factors, sex and age are some major risk factors of the disease. Oral contraceptives, environmental influences, stressful life style physical inactivity, and infections are some other less common risk factors of pathophysiology.
About the Pathogenesis of Atherosclerosis
The pathogenesis of Atherosclerosis is mainly related to the pathophysiology this is why both of the topics are being discussed here.
The pathogenesis of Atherosclerosis usually involves a series of complex events related to the arteries and coronaries. The complete pathogenesis process is usually related to or just can be said to be very similar to that of the chronic inflammatory process of the coronaries and arteries. As an end result of the pathogenesis of atherosclerosis the plaque which is also called the fat debris is collected into these arteries / coronaries.
The very first step of the Atherosclerosis process is the injury or damage in the endothelial artery cell. Now since the endothelial cell is damaged it then results in the complete dysfunction of it. The remaining endothelial cell then causes to attract the mucus cells. As a result of which the mucus get collected here in the arterial wall. Now an excessive amount of the tissue matrix is produces. This is just known to be the ultimate cause of formation of plaque. When these artery accumulated plaques get ruptured, thrombosis, emboli or plaque hemorrhage then the severe lesions can be found on the parts of it. The detailed study on the pathogenesis of Atherosclerosis is going on in order to discover its prevention methods.